羧甲(jia)纤(xian)(xian)维(wei)(wei)(wei)素钠是(shi)以纤(xian)(xian)维(wei)(wei)(wei)素为(wei)原(yuan)料，采用两步法(fa)制备羧甲(jia)纤(xian)(xian)维(wei)(wei)(wei)素钠。先是(shi)纤(xian)(xian)维(wei)(wei)(wei)素的碱(jian)化(hua)过程，纤(xian)(xian)维(wei)(wei)(wei)素与氢氧化(hua)钠反应后生成(cheng)碱(jian)纤(xian)(xian)维(wei)(wei)(wei)素，然后是(shi)碱(jian)纤(xian)(xian)维(wei)(wei)(wei)素与氯(lv)乙(yi)酸反应生成(cheng)羧甲(jia)纤(xian)(xian)维(wei)(wei)(wei)素钠，称为(wei)醚化(hua)反应。本法(fa)制得羧甲(jia)纤(xian)(xian)维(wei)(wei)(wei)素钠符合(he)药(yao)典要求，有很(hen)强的吸(xi)水(shui)膨胀性,促进药物的溶出速度,大大提高了药物的生物利用度。